The once raging stream has almost dried up today. For millennia, the river, called Amu Darya in Persian and Oxus in Greek, has produced cultural riches that radiate from China to Western Europe. Today it has become a symbol of man’s depletion of nature. But it is not only Central Asia’s nature that is threatened; traditional culture is also disappearing at breakneck speed and being displaced by globalization and devastation. Marc Sinan has made an extensive journey through Uzbekistan and, together with Markus Rindt, filmed musicians who have kept alive centuries-old musical traditions that have always been cosmopolitan. He presents the results of his research in the form of a chamber music suite, a road movie, for guitar, clarinet, harpsichord and percussion, which communicate with the video installations. Overlays, counter-theses and respectful comments on the video material open up an independent discussion.